He was the younger brother of the diplomat and statesman Alexander Karatheodori Pasha, who also served as Prince of Samos from 1885 to 1895.

He had also worked in Samos on the construction of the road connecting Vathy, Karlovasi, Marathokampos, Platanos, Pirgos and the capital, under Prince Miltiadis Aristarchis.

When he became Prince of Samos, he tried to reconcile the parties and bring peace to the island.

He made the same mistakes as everyone else before him, in that he championed the winning political party.

The opposite party did not want that and protested to the Ottoman government with the excuse that the establishment of a Samian bank was not a wise thing to do.