Alexios V Megas Komnenos (Greek: Ἀλέξιος Σκαντάριος Μέγας Κομνηνός, romanized: Alexios Skantarios Megas Komnēnos;[a] 1454 – 1 November 1463) was very briefly Trapezuntine emperor in April 1460, succeeding his uncle John IV, until his deposition by his other uncle, David.

[5] Alexander, who is also called Skantarios in some sources, was a son of the Trapezuntine emperor Alexios IV Megas Komnenos (r. 1417–1429) and had been his designated heir.

[11] Later sources state that the Ottoman sultan Mehmed II, who had conquered Constantinople in 1453, at some point took the young Alexios as one of his pages.

[5] On 15 August 1461, Mehmed II conquered Trebizond, and allowed Alexios's uncle David and his family to settle near Adrianople, but in 1463, the sultan accused them of plotting treachery.

[12] Perhaps these accusations derived from Trebizond at this time having been temporarily captured by Uzun Hasan of the Aq Qoyunlu, David's brother-in-law.