Andronikos III Megas Komnenos, or Andronicus III (Greek: Ανδρόνικος Μέγας Κομνηνός, romanized: Andronikos Megas Komnēnos), (died 8 January 1332) was Emperor of Trebizond from 1330 to 1332.

He was the eldest son of Emperor Alexios II of Trebizond and his Iberian wife, Djiadjak Jaqeli of Samckhe.

[1] Rustam Shukurov suggested that Andronikos and his son Manuel were named for their distant ancestors, Andronikos I Komnenos and his son Manuel the Sebastokrator, arguing that their portraits appeared on the walls of the Imperial palace hall.

[2] One of his first actions when Andronikos became emperor was to put to death his two younger brothers, George Azachoutlou and Michael Achpougas.

His other brother Basil managed to escape to Constantinople, where his uncle Michael was probably already residing.