Theodora Megale Komnene (Greek: Θεοδώρα Μεγάλη Κομνηνή, Theodōra Megalē Komnēnē), (before 1253– after 1285), was Empress of Trebizond from 1284 to 1285.

All Michael Panaretos tells us about her is that she was a daughter of Emperor Manuel I of Trebizond by Rusudan, a Georgian princess.

[2] Kuršanskis also notes that the evidence is insufficient to determine if Theodora was identical with one of the princesses of Trebizond mentioned in the Chronicle of Bishop Stephanos who married a noble or the king of Georgia, or if she had been a nun — much as Anna Anachoutlou was before her usurpation in the following century.

[3] In 1284, with the help of Georgian King of Imereti, David VI Narin she managed to seize the crown from her half-brother, Emperor John II.

A few types of silver aspers and bronze nomismas are evidence that she was the only Empress of Trebizond to have coined money.