Alexius Frederick Christian of Anhalt-Bernburg (12 June 1767 – 24 March 1834), was a German prince of the House of Ascania.

The territories of Anhalt-Bernburg were augmented one year later with the formal division of Anhalt-Zerbst in 1797; Alexius Frederick Christian received the towns of Coswig and Mühlingen, which represented 1/3 of the defunct principality.

Alexius Frederick Christian initiated several major construction projects, such as the Saalebrücke in Bernburg (Saale), which was later destroyed.

In matters of religion, he was tolerant and enlightened; in 1820 he finally declared the Reformist and Lutheran faiths to be the official co-religions of his state.

After the dissolution of the Holy Roman Empire, Alexius Frederick Christian, with his kinsmans the Dukes of Anhalt-Dessau and Anhalt-Köthen, joined the Confederation of the Rhine.