The Alfred Nzo District Municipality (Xhosa: uMasipala weSithili sase Alfred Nzo) is one of the 6 districts of the Eastern Cape province of South Africa.

The majority of its 801,344 residents speak isiXhosa.

It is named after Alfred Baphethuxolo Nzo, a former secretary-general of the African National Congress and the Minister of Foreign Affairs in Nelson Mandela's cabinet from 1994 to 1999.

The Alfred Nzo District Municipality contains the following towns: Mount Frere, Mount Ayliff, Maluti and Matatiele.

This Eastern Cape location article is a stub.