The Amathole District Municipality (Xhosa: uMasipala weSithili sase Amathole) is one of the 7 districts of the Eastern Cape province of South Africa.

Amathole means "calves", the name of the mountain range and forest which forms the northern boundary of the district.

[3] The Executive Mayor of Amathole District Municipality since 2016 is Anele Ntsangani, [] and the Municipal Manager is [Dr Bhekisisa J Mthembu].

Amathole is surrounded by: The district contains the following local municipalities: Raymond Mhlaba Local Municipality, following amalgamation of Nxuba (24,264; 2.72%) and Nkonkobe (127,115; 14.24%)] municipalities.

As of January 2024, the municipality is under administration, one of 32 in the country, and three in the Eastern Cape where the provincial executive has intervened due to maladministration[4]