The OR Tambo District Municipality (Xhosa: uMasipala weSithili sase OR Tambo) is one of the seven districts of the Eastern Cape province of South Africa.

It is within the Wild Coast Region.

As of 2011, the vast majority (94%) of its 1,364,943 inhabitants spoke isiXhosa.

The district is named after Oliver Tambo.

OR Tambo is surrounded by: The district contains the following local municipalities: After the 2011 municipal election, OR Tambo District shrunk, with Mbizana and Ntabankulu local municipalities being transferred to Alfred Nzo District Municipality.