They play as a member of the Liga Norte de México (LNM), a minor league organized farm system in Mexico and play their home games at Estadio Andrés Mena Montijo.

Algodoneros de San Luis was established as an amateur baseball club in 1945.

They later joined the Liga Norte de Sonora and briefly changed their name to Soles de San Luis (San Luis Suns), but quickly returned to their original nickname.

The Algodoneros played in the Liga Norte de Sonora until 2011, when the league split.

[4] Since 2022, the club is affiliated with the Sultanes de Monterrey of the Mexican League.