The fifth and final season of the American drama/adventure television series Alias premiered September 29, 2005, on ABC and concluded May 22, 2006, and was released on DVD in region 1 on November 21, 2006.

Between December 2005 and April 2006, the series went on hiatus due to Jennifer Garner's real-life pregnancy, which was written into the season's storyline,[1][2] as well as news of the show's cancellation.

Rachel's family is placed in the Witness Protection Program after growing concerns that her former boss Gordon Dean may attempt to kidnap them.

Afterwards, based on information from Sloane, who in turn was tipped by Gordon Dean, APO infiltrates a party in search for an electronic dossier that will give them the location of a weapons designer who has created a weapon using software referred to as the "Lasso software" that can redirect a missile mid-flight.

During this mission, Rachel is confronted by a guard, however, rather than fighting she runs and is eventually saved by agent Grace.

They later come to the conclusion that the only way to infiltrate the rig is to send a female agent that can pose as the designer's weekend "companion."

While on the rig, Rachel steals the Lasso software, however, she is confronted by Kelly Peyton, her former colleague and friend while at "The Shed".

Peyton was sent to the rig to retrieve the software after Dean was hesitant about trusting Sloane to make good on this transfer.

His obligations to Prophet 5 complete, the organization gives Sloane a hypodermic needle containing a Rambaldi-designed drug that will cure Nadia's comatose condition.

Later, Sloane smothers Nadia to death in her hospital bed; Jack arrives and, thinking Sloane is committing euthanasia, nearly prevents him from administering Rambaldi's drug in time, but Nadia is successfully revived with no apparent ill effects from her year-long coma.

In France, Renée seduces and later interrogates an old contact who has been given Rambaldi's Page 47 to decipher, but learns the artifact is a fake.

Back in Los Angeles, Jack is about to follow Sloane to a possible Prophet Five rendezvous when Nadia appears and asks to go along.

The rendezvous instead appears to involve Sloane recovering a suitcase full of Nadia's old clothes from a storage locker.

On the way to Rome, Sloane talks to Peyton, telling her that he wants to kill Anna (Sydney) once she has finished helping him recover the final clue.

After calling the police himself, Sark acts out a dramatic robbery in the bar in order to get both of them arrested; this is how they will get into the prison where the final Rambaldi clue is located.

When Sydney gets to the prison basement she meets an old man, who gives her a necklace complete with a red pendant, the final Rambaldi clue.

Once they gather the photos and information at the office, they decide to make the arrests simultaneously to avoid tipping the rest of the members off, including Sloane.

With Peyton, Sloane asks Marshall to hack into the government system and locate a cavern by accessing the federal ground-penetrating satellite.

As soon as Carrie arrives in the APO office, she cracks the password for Marshall's program to track Prophet Five members (which is Moonglum of Elwher).

Carrie sets up trip wires to monitor government hacks and pinpoint Marshal's location.

At the APO office, Carrie reports to Jack that based on Marshall's tracker, The Twelve seem to be gathering in Zurich.

Jack assumes that Sloane must be presenting the information that Marshall and Rachel uncovered and assembles strike team.

Standing in the middle of the room and expected to present the amulet, Peyton opens the briefcase and pulls out two semi-automatic weapons.

Peyton tells Sloane that she was able to make contact with their ally in Hong Kong, and that they have a deal as she reveals the Horizon.

In the safety of a hotel in Siena, Sydney flashes back to her childhood when she assembled building blocks, not realizing that this was part of Project Christmas - meant to test people's aptitude for being operatives.

Vaughn, Dixon and Sydney interrogate Peyton, and she tells them that she does not know where the missiles are stored now but she knows that Sloane is targeting two cities with high civilian concentrations.

As Sydney prepares to fly to Mongolia, Rachel reports that she and Marshall are trying to hack into optical satellites to locate the missiles.

Vaughn says Sloane is dead and that Sark must be taking the Horizon to their contact in Hong Kong--Irina Derevko.

Region 4 was initially supposed to receive Season 5 (5-Disc Set, PAL, Australia) on March 14, 2007, however Buena Vista postponed the title due to the Seven Network's delayed broadcast of the series.

The DVD set includes the final 17 episodes of the series, presented in Anamorphic Widescreen (1.78:1), along with English Dolby Digital 5.1 audio.