Created in 1976 thanks to Eusebio Sempere, and reopened in 2011 after a major renovation, the museum now consists of three permanent collections of about 800 art pieces.

Only one third of the Eusebio Sempere Collection is shown at a time with rotation every three to four months.

The museum building, in turn, is another example of modern art by Spanish architects Sol Madridejos and Juan Carlos Sancho.

Constructed originally as a granary it has also served throughout the history as jail, powder storage, school of commerce, and once as a temporary seat of City Hall.

The original building is a notable example of Alicante's baroque architecture.