[2] Lou spent her childhood in Kommetjie on west coast of the Cape Peninsula in South Africa and attended a Waldorf school.

[4] She has two younger brothers who are twins and grew up listening to Jimi Hendrix, Joni Mitchell, Leonard Cohen, The Velvet Underground and Portishead.

[9] She took a gap year after graduating from high school in South Africa in 2012, and settled in Europe, first to Amsterdam and then to Berlin.

[4] After her gap year she contemplated attending university in South Africa,[10] but eventually decided to purchase a battery powered amplifier and return to Berlin instead.

After a performance at TEDx in Berlin on 6 September 2014[15][16] she started to get offers from record labels, but she wanted to stay independent.

[23][24] In April 2016, Alice Phoebe Lou released her debut album "Orbit", produced by Matteo Pavesi and Jian Kellett-Liew.

[27][28] She toured in Europe, South Africa and USA in 2016 and played three sold-out shows at the Berlin Planetarium.

[37] "She" also features significantly in two scenes of the German Film Kokon, which was released on 21 February 2020 (When 'Nora' and 'Romy' are on the roof of a building, listening to music; and at the end, as 'Nora' finds her Caterpillar has metamorphosed into its adult form).

During 2018 Alice Phoebe Lou toured Europe, USA, South Africa, Japan and Canada.

[2] On 15 November Alice was interviewed in aspekte-program of German ZDF TV and she performed Paper Castles with her band.

[55][56] On 28 February 2020 German TV Bayerischer Rundfunk broadcast and streamed her PULS-festival concert recorded on 30 November 2019 in Munich.

[57] In spite of extensive touring Lou still continued to occasionally perform in Berlin parks and U-Bahn stations too.

[74][75] On 25 February 2022, while she was touring in west coast of USA,[76] her side project Strongboi released new song Fool Around.

[79] Touring continued in 2023 and on 10 March 2023 the title track Shelter of her coming album was released as a single in digital formats followed by a music video about month later.