Alie Street is a 400-metre-long street located in Whitechapel, in the London Borough of Tower Hamlets.

It links Mansell Street with Commercial Road in the East End of London.

For much of its history, the western part was known as Great Alie Street, with the eastern part called Little Alie Street.

Originally called Ayliff Street, it was named after a relative of William Leman, whose great-uncle, John Leman had bought Goodman's Fields earlier in the seventeenth century.

These new streets developed in the late seventeenth century while Goodman's Fields was used as a tenterground.