In Houston, Alief ISD serves the Alief community, almost all of the district of Westchase, Keegan's Glen, Leawood, Ashford Park, Bellaire West, Royal Oaks Country Club, Sharpstown, and the Southwest Management District.

In unincorporated Harris County, Alief ISD serves Wingate, portions of the Mission Bend CDP, and Enclave Crescent Park Village.

[9] The Alief ISD area is a part of the Houston Community College System tax base.

[13] To qualify for enrollment in a prekindergarten program, children must be 4 years old by the district's cut-off date.

[13] Children also must be either unable to speak or comprehend English or come from families which have a household income at or below the subsistence level as defined by the State Board of Education.

[13] Students between the ages of 5 years old and 21 may attend kindergarten through twelfth grade in the district.

[14] The maintenance tax rate was $0.9561 and the total operating financial sources for bonds and assets were $80,981,948.

Historical district TEA accountability ratings[3] Alief ISD has been named one of the top 830 districts that nationally received the National Award for Music Education in its fine arts education.

Alief ISD has an alternative elementary zoning boundary set for bilingual students, as some Alief ISD elementary schools do not offer bilingual programs.

In addition to school campuses, the district has several other facilities for students, staff, and administrators.

The Steven Lloyd Ness Natatorium, located on High Star across the street from the Hastings and Elsik campus,[67] houses the district's swimming pools.