[1] He was the Milliy Tiklanish's nominee for the 2021 presidential elections where he ran on several platforms that were aimed at reforms and changes and faced serious of controversies and scandals in regards on proposals to introduce income taxes for Uzbek migrants as well as accusations in plagiarism.

[2] During the COVID-19 pandemic, Qodirov supported the easing of quarantine restrictions telling that mortality of the virus are caused by unhealthy lifestyles and urged people to take care of their health by not overeating.

Qodirov in response to the parliamentary vote of rejecting the bill stated how Uzbek is an easy language to learn in regards to complaints by MPs about its difficulty, telling that "we'll come back to this question in 10 years if we're alive.

[11] Qodirov also proposed a controversial income taxes for Uzbek migrants living abroad which received opposition, most notably from his election challenger and incumbent President Shavkat Mirziyoyev.

[12][13] In the aftermath of the race, Qodirov took third place amongst candidates, winning 5.5% of the vote and falling behind People's Democratic Party of Uzbekistan (XDP) nominee Maqsuda Vorisova despite the Milliy Tiklanish having more advantages due to its previous performance in the 2019–20 parliamentary elections.