She is best known for her extensive work in musical theatre, notably for her roles as Elphaba in the First National Tour of Wicked and Jenna in the Broadway production of Waitress.
[4] Luff made her Broadway debut in the ensemble of Mamma Mia, understudying the roles of Ali and Sophie.
[6] Luff made her Wicked debut on April 30, 2013[8] with the 1st National Tour, alongside Jennifer Gambatese as Glinda.
[11] Luff then starred as Fantine in the second Broadway revival of Les Misérables from February 2016 until the production's closing in September 2016.
In October 2024, Luff is scheduled to take over the role of Anne Hathaway in the Broadway production of & Juliet, replacing original cast member Betsy Wolfe.