It was originally founded by Air One that merged with Alitalia in 2009 and was subsequently renamed.

[4] It commenced operations with flights between Trieste and Rome Fiumicino; and Genoa and Naples, on 7 June.

In February 2007, it started its first international route, between Turin and Paris-Charles de Gaulle.

Anew fleet of 20 Embraer 175s and 190s was delivered between September 2011 and March 2013.

In August 2019, the airline's parent company and CityLiner itself were placed under Extraordinary Administration (EA), this due to years of inprofitability.