[1] Alkmonton is mentioned in the Domesday Book of 1086, as Alchementune; it was held under Henry de Ferrers.

[1][2] In about 1100, when the manor was held by Robert de Bakepuze, a hospital for female lepers was built, dedicated to Saint Leonard.

It was refounded in 1406, leprosy having died out, by the widow of Sir Walter Blount, who held the manor.

His descendant Walter Blount, 1st Baron Mountjoy (died 1474) willed that a chapel, dedicated to Saint Nicholas, should be built at Alkmonton, and that the master of the hospital should say Mass there each year on the feast of St Nicholas.

[1][4] North and east of the site of the village are ridge and furrow patterns, surviving to a height of 0.5 metres (1 ft 8 in), of the medieval open-field system.