Construction began on the Spring Street campus, then known as St. Mary's Medical Center, in 1974, and the hospital finished moving in on August 20, 1977.

The previous day, the old site was sold to S. C. Johnson & Son, which annexed the buildings into its headquarters.

[2][3] St. Luke's Hospital opened in 1872, with the first part of the Wisconsin Avenue campus being constructed in 1876.

[2][3] St. Luke's and St. Mary's, as Racine's two primary hospitals, were direct competitors for decades.

They began formally cooperating in 1974, when they agreed to consolidate pediatric and obstetric services.