[4] For honeybees who pollinate this species, they will dive into the tube to reach the pollen, making their actions less effective than the work of the Amethyst sunbird.

[4] While their tube shape makes it harder for pollinators to reach the pollen, it does deter insects who eat the nectar of the flower, which can be a competitive advantage.

[4] Aloe lettyae produce a fruit that is green, and rather small, but is subject to a considerable amount of herbivory, both from birds and insects.

[4] The species naturally occurs in Limpopo Province in South Africa between Haenertsburg and Tzaneen and is restricted to this small area which has relatively high rainfall and granitic soils that are sandy and drains very fast.

Aloe lettyae is an endemic to endangered Woodbush Granite Grassland in Limpopo Province and occupies 123 km2 of land out of 17.5ha habitat.

Aloe lettyae were severely vegetation fragmented that clustered on south western of Wood Bush Granite Grassland less than 40km apart, varying from 10 to 6547 plants and approximately 10,800 individuals.

Research from Kohne et al. in 2020 showed that the Amethyst sunbird (Chalcomitra amethystina) is the main pollinator of this species, with honeybees (Apis) acting as a co-pollinator.

Also, due to changes in climate, wildfires have been more prominent and more common, which has resulted in an increase to more fire-resistant shrubs and bushes, and a subsequent decrease in Aloe lettyae populations in the area.

[7] Due to invasive species, transformations via farmland or livestock zoning, or general human activity such as littering and manmade fires[8] Aloe lettyae has been found to not be at risk to some common diseases.