Afterwards, he was nominated as Governor of the Río de la Plata, a position that he held between 1660 and 1663.
In 1662, he expelled the Society of Jesus from its initial location on the Plaza de Mayo, as its buildings interfered with shooting practices of nearby Buenos Aires' "fortress" (the current Casa Rosada).
His request for royal authorization to commerce with two foreign ships a year was denied.
Nonetheless, he allowed Dutch ships to dock in the Buenos Aires port.
Because of his tolerance for the contraband of goods and slaves, he was subjected to a tribunal of grievances, but the case was dismissed.