Santa Fe is home to the Sauce Viejo Airport with daily direct flights to Rosario and Aeroparque Jorge Newbery in Buenos Aires.

Santa Fe de la Vera Cruz became the commercial and transportation center for a rich agricultural area that produces grain, vegetable oils, and meats.

On April 29, 2003, the Salado, which empties into the Paraná near Santa Fe, rose almost 2 m (6.5 ft) in a few hours following heavy rainfall, and caused a catastrophic flood.

[3] There is infrastructure for tourism that has been developed: river side bars and nightclubs, chic restaurants, the improvement of the major highways and a subfluvial tunnel.

[citation needed] Despite having had four railway stations, nowadays the city Santa Fe is not served by rail transport.

The Mitre Railway station is no longer used since 2007, when defunct company Trenes de Buenos Aires cancelled its services to Santa Fe.

Likewise, the Santa Fe Belgrano (built in 1891 and named Cultural Heritage) and Guadalupe stations had been entered into disuse in 1993 when the railway privatisation in Argentina ceased all the long-distance services in the country.

[9] The fourth station (also the oldest of all) had been built by French company Province of Santa Fe Railway in 1885.

Santa Fe was also the place where the world known Amílcar Brusa was born and raised, and the home of boxers Carlos Baldomir and Julio César Vásquez.