After immigrating to the Oregon Country, he established Boones Ferry across the Willamette River south of Portland near the present city of Wilsonville.

[1][4] In 1846, Boone packed up his family and started west along the Oregon Trail himself, eventually taking the Southern Route to the Willamette Valley.

[5] After reaching the valley, Boone took up a land claim along the Willamette River on the south bank between Oregon City and Champoeg.

[2] Alphonso Boone died in California on February 27, 1850, along the Feather River near Oroville in Butte County.

[1][3] His daughter Chloe married neighbor and Oregon Territorial Governor George Law Curry in March 1848.