It relieves skin irritation from many causes, such as insect bites, athlete's foot, urushiol-induced contact dermatitis from plants poisonous to the touch such as poison ivy, oak, or sumac,[1] and skin irritation due to sensitivity to soaps, detergents, cosmetics, or jewellery.

Preparations are also used topically for the relief of a variety skin conditions such as eczema, diaper rash, acne, and pruritus ani.

In the USA medications containing aluminium acetate are sold under the brand names Domeboro Powder, Gordon's Boro-Packs, and Pedi-Boro Soak Paks.

This medication stops the growth of the bacteria and fungus and beneficially dries out the ear canal.

[4] US preparations for this purpose include Domeboro Otic, Star-Otic, and Borofair.