Sutherland has had an extensive runway, print and television modeling career, appearing in campaigns for Bulgari, Ralph Lauren, Garnier, Calvin Klein, Chanel, John Frieda, Kerastase, Hugo Boss and Abercrombie & Fitch.

[3] Sutherland has appeared on the cover of magazines for Vogue Australia, Harper's Bazaar Singapore and Japan, Elle Germany, Australian Style, Glamour Italy and Black and White.

Sutherland has worked with renowned fashion photographers, including Herb Ritts, Bruce Weber, Ellen von Unwerth and Steven Meisel.

Since transitioning away from modeling, Sutherland has expressed guilt about having contributed to the "unrealistic standards" of beauty set by the fashion-industry and has been critical of its "strict" and damaging size-requirements.

[6] Sutherland's acting-career includes roles in the films The Devil Wears Prada, Day on Fire and Arbitrage.