He is known for his role as Kieran Wilcox in the first two seasons of MTV's slasher series Scream.
Serafini started his career with a role in the short film Smoke (2013), and a minor role in the short web series Oh La La, Hollywood Speaks French!
[3] In 2018, Serafini guest starred as Josh in the web television series Impulse,[4] and starred as Terry in the independent comedy film Summer Days, Summer Nights.
[5] In 2023, he starred as Henry Van Horne in the independent action-thriller Hidden Strike alongside John Cena and Jackie Chan.
[6] In 2024, Serafini starred in the romantic comedy film Wallbanger directed by Tosca Musk.