She was born in Erfurt and was the oldest daughter of composer Johann Pachelbel.
According to Pachelbel's obituary retold in Mattheson's Grundlage einer Ehrenpforte of 1740, Amalia's interest in art pleased her father, and he was always supportive of her.
Amalia became known for her floral watercolors, copper engravings and porcelain pieces.
In 1730, seven years after her death, she was included in Doppelmayr's encyclopedia of important mathematicians and artists of Nuremberg (Historische Nachricht von den Nürnbergischen Mathematicis und Künstlern), as was her father.
A commemorative plaque installed on a house in Erfurt where the Pachelbel family lived mentions her as the "author of the first embroidery pattern (formula) textbook".