Campodónico was born in Rosario, Argentina, and studied music there,[1] before continuing her training in Milan.

[2] In 1897, Campodónico made her debut on the opera stage at the Gran Teatro del Liceo in Barcelona,[2] in Samson and Delilah, conducted by the composer Camille Saint-Saëns.

Also in 1897, she sang at the Teatro dell'Opera di Roma, in a company with Raffaele Grani [it], Eugenio Giraldoni, and Maurizio Bensaude.

[2] In 1899, she was lead mezzo-soprano of an Italian opera company when it toured in Mexico,[4] performing alongside Aristide Anceschi [ru].

In 1906 she was appointed as a music teacher; she taught at a normal school, and at the Williams Conservatory in Buenos Aires.