[10][11] On April 22, 2014, the New York Times website launched[12] its data journalism section, The Upshot, with Amanda Cox a graphics editor.

[13][14] Cox was named editor of The Upshot in early 2016, called "a rare intellect" and "a crucial part of the future leadership of The Times".

[17][18] In late 2017 Cox implemented a "live polling" feature at the Times, partnering with Siena College, allowing for election results in real-time.

[23][24][25] In her opening keynote in 2013, Cox said the design "wasn't ultimately about typography and whitespace, but about empathy—about creating visualizations that readers can both understand and engage with emotionally.

[27][28] In January 2022, after 16 years at the Times, Cox joined USAFacts, a non-profit centered in providing a single, unified resource for public data.