Here We Go Again (2018), Jennifer's Body (2009), Dear John (2010), Letters to Juliet (2010), Red Riding Hood (2011), In Time (2011), Les Misérables (2012), A Million Ways to Die in the West (2014), Ted 2 (2015), and First Reformed (2017).

[7] She enrolled at Fordham University in New York City in the fall of 2003, but chose not to attend after being offered a leading role in the 2004 film Mean Girls.

She appeared in several print ads for clothing companies, including Limited Too with Leighton Meester, and was featured on three covers of the Sweet Valley High novel series.

[10] While still a teen, she took vocal lessons, studied opera, trained with a Broadway coach, and began her acting career as an extra in Guiding Light, a daytime television drama.

[12] Seyfried's performance in the film earned her, along with Lohan, Lacey Chabert, and McAdams, an MTV Movie Award in the category of "Best On-Screen Team".

In 2006, she appeared in five episodes of Wildfire as Rebecca and played the lead role Chrissy in the short film Gypsies, Tramps & Thieves, written and directed by Andrea Janakas.

From 2004 to 2006, she made multiple guest appearances on several television series, including House, Justice, Law & Order: Special Victims Unit, American Dad!

[11] With her role in the HBO drama television series Big Love, Seyfried's profile as an actress grew substantially; the series centered on a fictional fundamentalist Mormon family in which Seyfried plays Sarah Henrickson, Bill and Barb's first daughter, who struggles with her family's polygamous faith.

In December 2009, HBO confirmed that Seyfried would return for the show's fourth season, but that it would be her last since she wished to begin concentrating on her film career and other upcoming projects.

In March 2008, Seyfried was cast in the comedy horror film Jennifer's Body as Anita "Needy" Lesnicki, the title character's best friend.

[4][23] Seyfried starred alongside Channing Tatum in Dear John, the film adaptation of the novel of the same name that was written by Nicholas Sparks.

[25] Kirk Honeycutt of The Hollywood Reporter wrote, "Seyfried gives the character and her relationship all she's got, but she can't do all the heavy lifting.

[27][28] Seyfried next appeared as the title character in the erotic thriller Chloe, released by Sony Pictures Classics on March 26, 2010.

[30] In the film, Seyfried's character is an escort who is hired to test a husband's faithfulness after his wife concludes that his fidelity could not be trusted.

[31] Seyfried's performance in the film received favorable reviews from critics, helping her gain industry acclaim and additional opportunities to play varied roles.

[38] In late January 2009, Seyfried was to appear in Myriad Pictures' adaptation of Oscar Wilde's comedy A Woman of No Importance.

Also in 2011, Seyfried became a spokesperson and model for Clé de Peau Beauté, a line of Japanese beauty products.

The film, and her performance, received acclaim from critics, and was nominated for an Academy Award for Best Picture and grossed a total of $440 million worldwide.

She was also signed to play the role of Ann Burden in the dramatization of the Robert O'Brien post-apocalyptic novel Z for Zachariah,[48] but was replaced by Margot Robbie following a delay in the film's production.

[53] In 2019, Seyfried starred as Eve in The Art of Racing in the Rain, a comedy drama based on best selling book of the same name.

[56] She received critical acclaim for her third film of the year, playing actress Marion Davies in David Fincher's Mank, which earned her Golden Globe[57] and Oscar nominations.

[64][65] In 2010, Seyfried was selected as brand's muse, ambassador and official spokesperson for French-Japanese luxury skincare house Clé de Peau Beauté.