For her role in Alexander Payne's road dramedy Nebraska (2013), she was nominated for the Academy Award for Best Supporting Actress.

[4][5] She has also acted in I'll See You in My Dreams (2015), Love the Coopers (2015), Other People (2016), Blow the Man Down (2019), Palm Springs (2020), Hubie Halloween (2020), Palmer (2021), The Humans (2021), and Family Squares (2022).

[12] Five years later she made her big screen debut playing a supporting role in the romantic comedy film Alice by Woody Allen.

[12] During the 1990s, Squibb also played supporting and minor parts in the films Scent of a Woman (1992), The Age of Innocence (1993), In & Out (1997) and Meet Joe Black (1998).

On television, she had a recurring role in the ABC daytime soap opera All My Children and made guest starring appearances on prime time series, such as Law & Order, ER, Just Shoot Me!, Judging Amy, Two and a Half Men and Curb Your Enthusiasm.

She also appeared in the made-for-television films A Stranger's Heart (2007) and Shark Swarm (2008) and guest-starred on The Middle, Castle and Mike & Molly.

[15] In 2013, Squibb starred opposite Bruce Dern in the road comedy-drama film Nebraska, directed by Alexander Payne.

[28] She also appeared in the films Other People (2016), Father Figures (2017), Blow the Man Down (2019), Palm Springs (2020), Hubie Halloween (2020), The Humans (2021) and Family Squares (2022).

She also played Mrs. Danforth, a rich benefactor, in "The Indoor Arm", the final episode of the second season of the Apple TV+ series Little America.

[31][32][33][34] Mae Abdulbaki wrote in her Screen Rant review: "June Squibb proves she's still on top of her acting game in an energetic, charming adventure comedy that is actually genuinely funny.

[36] Squibb starred in another leading role in Scarlett Johansson's directorial debut film Eleanor the Great.