[11][12] Head coach Mike Vrabel named Hooker the third free safety on the depth chart, behind starter Kevin Byard and primary backup Joshua Kalu.

On January 19, 2020, Hooker made the first catch of his career on a 28-yard reception by punter Brett Kern in the Titans' 24–35 loss at the Kansas City Chiefs in the AFC Championship Game.

[16] Head coach Mike Vrabel named him the primary backup safety to kickoff the season, behind starters Kevin Byard and Kenny Vaccaro.

He sealed the victory in the fourth quarter after intercepting a pass by Kirk Cousins intended for wide receiver Adam Thielen, but was deflected by teammate Kevin Byard.

Following the release of Kenny Vaccaro, Hooker competed against Dane Cruikshank and Matthias Farley in training camp to takeover at starting free safety.

[23] On September 12, 2021, he started the Tennessee Titans' home-opener and made six solo tackles and a six-yard reception before injuring his foot and exiting the 13–38 loss to the Arizona Cardinals.

Hooker finished the season with 62 combined tackles (38 solo), four pass deflections, one interception, and a forced fumble while starting all 12 games he appeared in.

Defensive coordinator Shane Bowen retained Hooker as the starting free safety, alongside Kevin Byard, to kick off the regular season.

During Week 13 against the Indianapolis Colts, he scored a rare defensive two-point conversion after intercepting a tipped pass thrown by Gardner Minshew.

[36] On December 22, 2023, the Tennessee Titans officially placed Hooker on injured reserve due to a knee injury and he remained inactive for the last three games (Weeks 16–18).

[39] On January 22, 2024, the Tennessee Titans officially hired Cincinnati Bengals' offensive coordinator Brian Callahan as their head coach.

[40] Throughout training camp, Hooker competed Quandre Diggs, Elijah Molden, and Jamal Adams for a role as a starting safety under new defensive coordinator Dennard Wilson.

[45] He finished the season with 71 combined tackles (47 solo), a career-high nine pass deflections, five interceptions, and two forced fumbles in 14 games and 14 starts.