is a global affairs interview television program hosted by British-Iranian journalist Christiane Amanpour, airing weeknights 6pm GMT/ 1pm ET & 7PM CET on CNN International.

Ambassadors to India, Afghanistan and Pakistan, Mohamed ElBaradei, Hans Blix, NATO Secretary General Rasmussen, Gen. McChrystal, the first-ever joint interview with media power couple Tina Brown and Harold Evans, Gen. David Petraeus, and the then Vice President, now former President of Nigeria, Goodluck Jonathan.

On August 20, 2016, Amanpour was also aired on CNN Philippines via tape-delay as a dry-run, but was axed a week after premiering on the network's local programming for unknown reasons.

It eventually returned on August 31, 2016, albeit the program would broadcast on an occasional basis when Philippine affairs that affect the global stage are featured.

The program relaunched full-time by January 1, 2018, replacing timeslots formerly occupied by the local franchise's Global Newsroom and the early evening edition of Sports Desk (both were axed due to network reorganization); thus extending its coverage to other international issues which were formerly featured in the former.

On September 10, 2018, as part of a revamp of CNN International's European primetime line-up, Amanpour moved to the 19.00 CET/18.00 UK timeslot and expanded to be a one-hour show.