In 2019, ANB acquired Lubbock National Bank, expanding its locations beyond the Texas Panhandle and into the South Plains and other parts of the state.

[1] As ANB, the bank operates 19 branch locations in and around the cities of Amarillo, Borger and Canyon.

Under the name Commerce National Bank, it operates seven locations in the cities of Bryan, College Station, Fort Worth, and two suburbs of Austin.

[14] In addition, the bank invests heavily in the financial education of Texas residents with its ANB Smart program, and participates in the national Teach Children to Save campaign and the Get Smart About Credit program from the American Bankers Association.

Ware, one of the earliest settlers in the area, became vice president of First National Bank in 1895 until moving to Fort Worth, Texas in 1899.

The current owners of Amarillo National Bank represent the fourth and fifth generations of the Ware family.

[18] The younger Wares were originally elected to director positions on Amarillo National Bank's board in 2008.