[6] In late 2015, Amazon began trial cargo runs out of Wilmington Air Park under the code name Project Aerosmith.

[7] In March 2016, Amazon acquired options to buy up to 19.9 percent of Air Transport Services Group's (ATSG) stock and began scheduled operations with 20 Boeing 767 aircraft.

[11] As of June 2018, Amazon Air had 20 of its 33 cargo planes based at the Cincinnati/Northern Kentucky International Airport (KCVG), with the rest flying point-to-point transit routes across the United States.

Amazon Air was planned to move into office space at the former Comair headquarters by March 2018, but this did not come to fruition.

[21][22] In September 2022, a study conducted by the Chaddick Institute found that Amazon Air had a system expansion of 5.8% without having added any additional warehouses.

[23] The study also showed that in the same year, the carry capacity had increased, making it 14% and 23% as large as FedEx Express and UPS Airlines, respectively.

[23] In October 2022, Amazon announced the lease of ten Airbus A330-300P2F freighters from Altavair to be operated by Hawaiian Airlines.

The service planned to use two, branded Boeing 737-800 freighters to deliver goods in four metro cities: Delhi, Mumbai, Hyderabad, and Bengaluru.

The company stated it had planned to increase the number of dedicated freighters in India to six by the end of 2023, and that it would also continue to utilize the cargo space of other passenger airlines.