[3] Species of the genus Amazophrynella are small toads measuring 12–27 mm (0.47–1.06 in) in snout–vent length.

The parotoid glands are absent, as are vocal slits and tympana.

[2] Species of the genus Amazophrynella are pond breeders, which is presumably an ancestral trait in bufonids (most Dendrophryniscus breed in phytotelmata).

[2] Amazophrynella was separated from Dendrophryniscus in 2012 based on molecular genetic evidence that indicated deep divergence between an Amazonian and an Atlantic Forest clade, the latter retaining the name Dendrophryniscus whereas the former was described as a new genus Amazonella,[2] later amended to Amazophrynella because of homonymy.

[3] The following species are recognized in the genus Amazophrynella:[3][4] Rojas, Carvalho, Ávila, Farias, Gordo, and Hrbek, 2015 Kaefer, Rojas, Ferrão, Farias & Lima, 2019 (Izecksohn, 1994) Mângia, Koroiva & Santana, 2020 Rojas-Zamora, Chaparro, Carvalho, Ávila, Farias, Hrbek, and Gordo, 2016 Rojas, Carvalho, Ávila, Farias, and Hrbek, 2014 Rojas, Carvalho, Ávila, Farias, Gordo, and Hrbek, 2015 (Melin, 1941) Rojas-Zamora, Fouquet, Ron, Hernández-Ruz, Melo-Sampaio, Chaparro, Vogt, Carvalho, Pinheiro, Ávila, Farias, Gordo, and Hrbek, 2018 Rojas-Zamora, Fouquet, Ron, Hernández-Ruz, Melo-Sampaio, Chaparro, Vogt, Carvalho, Pinheiro, Ávila, Farias, Gordo, and Hrbek, 2018 Rojas-Zamora, Fouquet, Ron, Hernández-Ruz, Melo-Sampaio, Chaparro, Vogt, Carvalho, Pinheiro, Ávila, Farias, Gordo, and Hrbek, 2018 Ávila, Carvalho, Gordo, Kawashita-Ribeiro, and Morais, 2012 Rojas-Zamora, Fouquet, Ron, Hernández-Ruz, Melo-Sampaio, Chaparro, Vogt, Carvalho, Pinheiro, Ávila, Farias, Gordo, and Hrbek, 2018