Mexico and the United States have maintained diplomatic relations since 12 December 1822.

[1][3] The first Mexican legation was composed by just four members:[4][5] The first street address registered by the group when President James Monroe conferred diplomatic recognition on 12 December 1822[6] was the Strother's Hotel,[7] on Pennsylvania Avenue and 14th street.

[8] The legation, however, lacked enough funds to settle in Washington, D.C., and had to rent a property in Philadelphia.

[4] The following list includes every head of the legation recognized by Mexican Secretariat of Foreign Affairs.

[1] Since this is an official list, there are some omissions, such as Emeterio de la Garza, Jr., a special representative of Victoriano Huerta who tried to secure recognition for its administration between 1913–1914.