Ambrose is an unincorporated community in Grayson County, Texas, United States.

[1] Ambrose is situated on the intersection of Farm to Market Road 1897 and U.S. Highway 69.

The Denison, Bonham and New Orleans Railroad built a stop in Ambrose.

A post office was opened in September 1902, with James B. Moore as postmaster.

The railroad stop was closed by 1927, and the post office was moved to nearby Bells in 1930.