U.S. Route 69 (US 69) is a north–south United States highway that runs from Port Arthur, Texas to Albert Lea, Minnesota.

In Texas, US 69 runs from Port Arthur near the Gulf of Mexico to the Texas–Oklahoma state line just north of Denison.

Just after the intersection with US 90, I-10 splits from the multiplex and resumes its easterly course, leaving US 69, US 96, and US 287 heading northwest through Beaumont.

In Lumberton, US 96 splits from US 69 and US 287 and heads northeast towards Jasper, while US 69 and US 287 continue on a northwest path towards Woodville.

US 69 and State Loop 287 continue until the intersection of SH 103 and Business US 69 on the northwest section of Lufkin.

US 69 continues on a north to northwest path through the towns of Alto, Rusk, Jacksonville and Bullard.

There, as it begins to enter the city, a Business route of US 69 turns off to the right to serve the downtown Greenville area, and then on to a junction with Interstate 30.

As part of the I-14 System in Texas project, US 69 between Woodville and Beaumont is proposed to be upgraded to interstate standards.