He lived during the 18th dynasty and was the eldest son and designated heir of Thutmose I.

[1] Amenmose is depicted in the el-Kab tomb of his and Wadjmose's tutor, Paheri.

A fragment of Amenmose's small stone naos has also been found dated to year 4 of Thutmose I. Amenmose's name was written in a cartouche, which was usually restricted to pharaohs and their chief queens; it was rare for a crown prince to be identified in this manner.

[1][2] Amenmose was the first Egyptian prince to receive a military title (that of "Great Overseer of Soldiers"), reflecting the role of pharaohs and princes as generals.

This title first appeared during the Middle Kingdom and was later used frequently for princes during the Ramesside period.