[1] Having originated in Buffalo, New York, United States, Flight 2207 took off from an undefined airport in Detroit, Michigan, United States on a scheduled flight to Chicago, Illinois, United States carrying 3 crew and 18 passengers, including Captain Frank Mapes Ham Jr. and First Officer Harman Edwin Ring on December 28, 1946, at 07:48, which was six minutes behind the scheduled takeoff time.

[2] However at 09:18 the pilots reported to Air traffic control that both engines had shut down and the aircraft had descended to an altitude of 900 ft (274 m).

Unfortunately the aircraft had lost too much altitude to safely make it to the runway and crashed near Michigan City at 09:19.

[3] The Douglas DC-3 C-50A involved, NC15577 (msn 4805) was built in 1941 and was used by American Airlines during its final flight.

An investigation of the accident determined that fuel starvation led to the failure of both engines which then started to accumulate carburetor ice.