Caroline White corresponded with Frances Power Cobbe, the woman who led the Victoria Street Society and had the Cruelty of Animals Act passed.

Additionally, it was issued by the British Anti-Vivisection Society as a pamphlet shortly after it was first published in Harper's Magazine in late 1903.

Anti-vivisectionists spent the next three decades trying to achieve legislation at state level but only succeeded on a national scale until the 1960s.

[2] The publication changed its name a number of times, from The Starry Cross in 1922, The A-V in 1939, and resting finally with AV Magazine some years after that.

[9] The group intends to illustrate how science and biology can be taught in schools without actually using animals, like with dissection in the classroom.

The group has created what they call the Science Bank which is a program of "new and innovative life science software and educational products that enable educators and students to learn anatomy, physiology, and psychology lessons without harming animals, themselves, or the Earth.