Much of AmCham's advocacy efforts begin in one of 26 committees, whose fields of activity range from agro-chemical, banking, and semiconductor to digital economy, public health and travel & tourism.

[5] Once a year, an AmCham delegation meets with senior officials in the U.S. administration and on Capitol Hill to discuss international business concerns regarding U.S.–Taiwan trade and commerce.

A late 2022 AmCham Taiwan survey found that 33% of company respondents said their operations were "significantly disrupted" amid rising tensions in cross-strait relations.

[8] U.S. companies played an important role in laying the groundwork for Taiwan's later economic achievements in the consumer electronics, computer, semiconductor, and flat panel display industries.

[10] American firms also helped advance Taiwan's 10 Big Projects, which in the 1970s provided the infrastructure foundation for the island's future economic prosperity.

Established in 1980 and inspired by the Stanford Research Park that nurtured Silicon Valley, Hsinchu has helped foster the development of some renowned global technology companies.

Following the shock of U.S. recognition of the People's Republic of China, AmCham's leadership played an instrumental role in determining the form of the continued U.S. relationship with Taiwan.

[11] In 1976, under the chairmanship of Marinus "Dutch" van Gessel, AmCham made the strategic decision not to oppose the improvement of U.S. relations with mainland China—as long as it was not done at the expense of Taiwan.

"[12] In his remarks, Parker emphasized that "normalization" jeopardized American economic interests in Taiwan and offered specific proposals for correcting the proposed legislation's failure to provide adequately for the security of Taiwan from threat or use of coercion from mainland China, as well as failure to offer a clear and sufficient legal framework for the continuation of U.S.–Taiwan relationships sufficient for continued trade and investment.

[11] Parker noted that the prompt enactment of these specific proposals "would not only be in the interest of American business, [but also] necessary to meet our country’s moral responsibilities to Taiwan and its people.

As the U.S. embassy in Taipei wrapped up its operations, AmCham stepped in to serve as the main conduit for communication with the Taiwan authorities to preserve or establish needed expatriate community organizations.

The chamber helped to create the Taipei Youth Program Association to provide recreational opportunities for expat children, and arranged for a new and larger location for the American Club in China (ACC).