AMSA authored the Patient and Physician Safety and Protection Act of 2005, introduced by Senator Jon Corzine (S. 1297) and Representative John Conyers (H.R.1228).

[citation needed] In addition to sponsoring events highlighting prospects for universal health care, medical technology, and HIV/AIDS, AMSA also has nixed the PharmFree Campaign to educate and train its members to interact professionally and ethically with the pharmaceutical industry.

Since the merger, AMSA now is able to offer international exchanges for research[5] and clinical[6] electives to nearly 70 countries through SCORE and SCOPE, respectively.

The PharmFree project, established by the AMSA in 2002, was created from the belief that the medical profession needs more detachment from pharmaceutical firms.

The PharmFree campaign has included a march on Pfizer offices in New York City, where members assembled at the firm's front doors and dumped thousands of pens marked with the company's logo on the doorstep.

Additionally, under the leadership of then-President Leana Wen, AMSA started the Counter Detailing Campaign in 2005 to encourage physicians-in-training to educate practicing physicians about alternative sources of information regarding pharmaceuticals.

Forty schools received an “F” for their lack of policies or encouraging physicians-in-training to obtain information from drug representatives.