[7][8] Coinciding with its 120th anniversary, a fifth and the largest branch, King Hamad American Mission Hospital, was opened in A'Ali on 26 January 2023.

The articles of association were signed in New York in August 1889, and the organization began formally with eight trustees and two graduates missionaries, Samuel Zwemer and James Cantine.

[8][14] James Cantine went to Basrah in Mesopotamia, in August 1892, and immediately started building a school and a hospital there, while Zwemer traveled to Bahrain.

After Zwemer came back to Bahrain with his bride, the now husband-wife team continued to run the clinic, dispensary, and bookshop, all from a rented house in Manama souq.

In 1901, the then Hakim of Bahrain Isa ibn Ali Al Khalifa helped them purchase land for the construction of a hospital complex to replace the mission house.

[15][16] Soon after the hospital opened, it began to attract thousands of patients from across the Gulf; from places like Qatif, al-Hasa, Oman, Qatar, Najd and Bushire.

[17][18] Even though another hospital, in memory of Queen Victoria who died in 1901, was set up by the British in 1905, on the requests and donations of some Hindu merchants in Bahrain, it was not consistent in its functioning.

In 2000, the hospital opened its first satellite clinic in Saar,[23][5] on the western side of Bahrain, offering dental and medical services.

The same year, a bridge connecting two hospital buildings across the busy Isa Al Kabeer road in Manama was opened.

[5] In 2018, a new Zwemer Clinic was also opened, in the main Manama branch premises, on 5 March, to cater to those in the low income groups with financial needs.

When Dr Sharon J Thoms arrived in Bahrain on September 11, 1900, no one could have been more relieved to see his new colleague "take up the medical work and make it worthy of that name" than Rev.

And the cutting of bone, stitching of skin, and dressing of this man's stump, while men around him were fainting – as they saw the procedure – was Dr Thoms' official initiation into medical and surgical work in Bahrain.

The whole family showed signs of gratitude, but the father weeping covered my hands with kisses and my head with blessings" (Field Reports and Quarterly Letters from the Arabian Mission, July–Sep 1900, No.35, Page 6).

[13][1][2] The hospital has placed the pictures of all the past Chief Medical Officers, who served over the last hundred years, with their names and tenures, on a wall in its main Manama branch, near its ENT Department.

In 2017, as a part of its strategic development goals, the hospital's board of directors, representing the Reformed Church in America, reorganized senior leadership positions.

[28] Some chief medical officers, doctors, and other staff have also written books on their experiences at the American Mission Hospital of Bahrain, and on other matters, of their personal interests.

[46][47] In 2015, AMH was listed among the best hospitals in the Arabian Gulf region by the International Socrates Committee based in Oxford, England.

[48] On 10 August 2023, CMC Vellore invited Dr George Cheriyan, the CEO of AMH to give the 12th Annual Dr. Ida S. Scudder Humanitarian Oration, and presented him with a citation and award, for his work.

[57] It had had the OHSAS 18001:2007 earlier[58] The hospital is also the authorized international training centre for the American Heart Association and conducts courses like Basic Life support (BLS), Advanced Cardiovascular Life Support (ACLS), Heart Saver and First Aid courses[59] for healthcare workers as well as for all those interested.

[72] In March 2022, it participated in the World Down Syndrome Day (WDSD) Walk for Fun event, organized in collaboration with OneHeartBahrain and Lulu Hypermarket.

It is held under the patronage of King Hamad bin Isa Al Khalifa, at his private golf course in Saffriya.

[82] Among those who had teed off on this golf course are world leaders like George Bush Sr. and Fidel Ramos, professional golfers like Scott McCaw and Chris Kelby and celebrity sportspersons like Boris Becker.

In A’Ali too, a new wellness centre with the latest state of the art equipment and facilities is also being built, at the King Hamad American Mission Hospital scheduled to open in 2022.

It began more than a century ago, with the arrival of a group of remarkable and selfless individuals who founded the American Mission Hospital in Manama.

[97]" On 27 September 2016, in New York City, King Hamad bin Isa Al Khalifa was presented the Samuel Zwemer award by the Reformed Church of America (RCA), in recognition of his prominent support for the American Mission Hospital and for health services in general, in the Kingdom of Bahrain, as well as for the king's keenness to promote freedom of religion.

[98][99] On behalf of the King of Bahrain, the then Minister of Foreign Affairs Shaikh Khalid bin Ahmed Al Khalifa had received the award from RCA's Secretary General Mr. Tom de Vries.

[101][102] It showcased the long history of Bahrain-US relationship through American Mission Hospital service for nearly 120 years by providing healthcare to the community of Bahrain.

Shaikh Nasser unveiled the details of King Hamad Global Centre for Inter-faith Dialogue and peaceful Co-existence on the occasion.

On 26 June 2019, King Hamad bin Isa Al Khalifa received the hospital leadership at his Qudaibiya Palace, in connection with this expansion project.