The American Museum of Science and Energy (AMSE) is a science museum in Oak Ridge, Tennessee, designed to teach children and adults about energy, especially nuclear power, and to document the role Oak Ridge played in the Manhattan Project.

The museum has both permanent and rotating exhibits, including robots, science puzzles, a NOAA weather station, a timeline of atomic discoveries, a large Van de Graaff generator, a display devoted to nuclear weapons and the Y-12 Plant, and a solar energy demonstration project.

Its flagship exhibit, titled "Secret City - The Oak Ridge Story", was completely redesigned and rebuilt in 2007.

A World War II-vintage flat top house, one of many inhabited by Manhattan Project workers in Oak Ridge, opened as a walk-through attraction in 2009, but was moved to the grounds of the Children's Museum of Oak Ridge in 2018 and is now used by the Manhattan Project National Historical Park as part of a display of the history of Oak Ridge.

The museum was free to the public for many years when its operation was fully funded by the U.S. federal government, but now charges for admission.