[4] AUC purchased a parcel of land in the village of Cupecoy on the Dutch side of St. Martin and construction of a permanent campus began in July 1996.

[6] Hurricane Irma struck Sint Maarten on September 5 and 6 2017 and the AUC campus, including the dormitories, suffered minor damage.

The school arranged for students to start the next semester on September 29, 2017, having made an arrangements with a North West England university (University of Central Lancashire) to share their facilities until students were able to return to the Sint Maarten campus.

After completing the initial 5 semesters (20 months)[8] of study in the Medical Sciences portion on AUC's St. Maarten campus, students then conduct 4.5 semesters (18 months)[8] of training in the Clinical Sciences portion (also known as the Clinical Years) at AUC's affiliated community hospitals, whereby the students may choose between community hospitals in the United States[9] or The United Kingdom.

[11] AUC is included in the list of approved schools recognized by the Medical Board of California.

AUC graduates (post September 2019) are eligible for registration with the General Medical Council in the United Kingdom, which as a result means that graduates can complete postgraduate (residency) training or work at any stage of their careers as practicing clinicians in the UK.

[19] The US Department of Education reported that the median total student loan debt for Americans who completed the AUC medical program was $331,634 (as of 2019).