It is located at 680 Park Avenue on the Upper East Side of Manhattan, and was established by David Rockefeller in 1965.

"[2] The Americas Society Building is listed in the National Register of Historic Places.

The building was previously the Percy Rivington Pyne House before serving as the Soviet Mission to the United Nations until its current usage.

Along with the neighboring buildings of the Queen Sofía Spanish Institute and the Italian Consulate General, the house constitutes one of the few remaining unified architectural ensembles on Park Avenue.

The Americas Society organizes interviews, speeches, podcasts, exhibitions, readings, and musical performances at its headquarters and reports on Congressional updates, and local events.