Via Rail passenger trains continue to stop at the station, with checked baggage handled by on-train crew members.

[1] The Intercolonial Railway (ICR) opened its line from Truro to Moncton on 9 November 1872.

Initially the ICR served Amherst passengers from a station constructed of wood on the same site as the present-day structure.

The present structure was opened on 31 August 1908 and is constructed of local red sandstone.

Several minor modifications have been undertaken to the structure in recent decades, including removing the south wing in 1975, replacing the bottom exterior stone in 1991 with stone from the Roman Catholic Church once located on Prince Arthur Street, and in 1992 new metal exterior doors were installed.