Aminoshikimate pathway

The aminoshikimate pathway was first discovered and studied in the rifamycin B producer Amycolatopsis mediterranei.

Its end product, 3-amino-5-hydroxybenzoate, serves as an initiator for polyketide synthases in the biosynthesis of ansamycins.

[1] Floss and coworkers identified the gene cluster associated with the aminoshikimate pathway in Amycolatopsis mediterranei.

[2] The enzyme-catalyzed condensation of 1-deoxy-1-imino-D-erythrose 4-phosphate with phosphoenolpyruvate to form 4-amino-3,4-dideoxy-d-arabino-heptulosonic acid 7-phosphate has been proposed to be the first committed step in the aminoshikimate pathway.

[3] In addition, kanosamine biosynthesis has been directly implicated by Guo and Frost as the source of the aminoshikimate pathway's nitrogen atom.